A Monthly Summary of News and Events
Vol. 7 No. 2 - February 2004
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According to recent statistics, Boccaccio might have also been refering to America in the last decade. In 1990 half a million children were diagnosed with the disease. In less than 8 years it multiplied eight-fold, to 4 million school-aged victims, infecting an astounding 10 percent of the entire school-age population. In some parts of the country nearly half the school children were said to have succumbed. Adults were also not immune. As many as 13 million adults currently are afflicted. Although no infectious agent has been uncovered, these numbers suggest an epidemic is upon us. I am refering to, if you haven't already guessed, Attention Deficit Hyperactivity Disorder.
By some estimates, one in six school-aged children suffer from ADD or ADHD. "With the exception of AIDS, there are few examples of such a rapid spread of a serious condition in recent years," says Gene Haislip, a former deputy assistant administrator at the Drug Enforcement Agency. AIDS is a severe, potentially lethal disease. At its peak in the US (1993) 102,000 new cases were diagnosed each year. But that same year ADHD struck 20 times this number. Fortunately the production of Ritalin kept pace! A rise of more than 700% over the past 10 years. And although America may be ground zero for the ADHD epidemic, it crossed the pond with a vengeance: Britain witnessed a 35,000 % increase in ADD cases in five years, from 2,600 cases in 1992 to 92,000 in 1997. Seven years later and there's no stopping it: current estimates now hover at half a million, many undiagnosed. "Too many children are 'slipping through the net'", sais a Dr Val Harpin, of Sheffield Children's Trust. Only 70,000 children are receiving medication; the National Institute for Clinical Excellence recommends that 100,000 children should. A lot of small pills are not being swallowed.
Although I would object to comparing ADHD to the AIDS epidemic, mental disorders can be nearly as devastating, emotionally and intellectually. Childhood ADHD is associated with an increased frequency of psychopathology in later life (Wender, et al., 1981). About two-thirds of children continue ADD symptoms into adulthood. Researchers have consistently found higher rates of antisocial personality, conduct, oppositional defiant, substance use, and anxiety disorders in adults with ADHD. Serious delinquent and psychological outcomes are associated with ADHD. ADHD children are at greater risk for chemical dependence (Clopton et al., 1993; Wilens, et al., 1995). Substance abuse disorders were found in 28% of children with ADHD, 8% of ADHD children who no longer showed symptoms in adolescence, and in only 3% of non-ADHD children. ADD children often progress from substance abuse to addiction in a shorter time period than other children. Milin (1991) found ADHD in one quarter of all substance abusers he examined butno cases of ADHD in non-substance abusers, so this epidemic shouldn't be underestimated. Or should it? Is there really an epidemic underway? And if so, what triggered it?
Epidemics. What causes epidemics? What ignites them, fuels them? When an unfamiliar and virulent germ enters a virgin population, an epidemic often follows. True? But where did the new germ come from? Some would say epidemics are the price we pay for living together, living in crowded cities. Humans are the highways upon which microorganisms test out this year's newest models. But often the germ responsible for an epidemic isn't particularly new to the scene; the population is.
Epidemics have plague humankind since our inception. Hippocrates wrote about them two thousand years ago. He also wrote about endemic diseases, which are more common. Endemics are epidemics past their prime, making the rounds after an original assault against a more resistant folk. By this definition ADHD is an epidemic, not an endemic condition. It is Round One, people, and there have been hundreds of Round Ones throughout history.
The first documented epidemic struck the Persian army in 480 BC. Xerxes led an army of 800,000 men into Thessaly, but had to withdraw when he lost a third to plague and dysentery. History is replete with similar examples: microbes striking a target that artillery could not reach. The First Crusade ended when an epidemic killed 80 percent of the horses. I would have gone home after that, presuming the Hand of God (or Allah) was at work. The Second Crusade suffered 100,000 losses to disease. Every campaign has incurred two fronts: one manned, one microbial. By the 19th century it was not unusual for disease to create more casualties than weapons of war. Typhus, cholera, smallpox, diphtheria. World War I ended as it did, and with the problematic terms that led directly to number II, in part, because of flu.
The three most devastating epidemics in human history were the Black Death, a combination of (presumably) bubonic and pneumonic plagues which struck Europe in the mid 14th century and reduced the population by a third; the 1918 influenza epidemic which killed three times as many people than the surrounding World War; and the current AIDS epidemic.
Ring around the rosies,
A pocket full of posies,
Ashes, ashes!
We all fall down.
(Children's rhyme, from plague-ridden England)
Black Death is thought to have been carried into Europe in 1347 by sailors from the Black Sea, and it may have been history's first and most successful act of biological warfare. As part of their seige tactics, the Tartars catapulted plague-infested bodies over the city walls of the port of Kaffa. The defending Genoese contracted plague and left, spreading the disease throughout the Mediterranean Basin. The 1918 influenza epidemic was called "Spanish flu" because of an early report in Spain, but the responsible virus evolved in American pigs and was spread around the globe by U.S. troops mobilized to fight the Kaiser. Even the peace conference at Versailles was affected as President Woodrow Wilson, the Prime Minister of Great Britain, and Premier of France all contracted the disease. As for AIDS, there are many theories about its origin, but I'm partial to the simian theory.. Milder strains of HIV have been carried with us for millions of years, but the end of European colonization in Africa lead to populations mixing as never before on the continent. Two extremely virulent strains of HIV emerged as a result. Without the increased traffic and contact between individuals, such strains would have burned themselves out in a decade or so, infecting one or two villages at the most. But truck and jet transporation changed all that.
Although epidemics can occur for any number of reasons, many share a common element. What kicks a local mutated microbe onto the world's stage? What is the epidemic catalyst?
Power. The endless human pursuit for power. Also called politics or money on occasion. Appropriation of wealth and power by any means possible. Invasion, conquest, exploration, trade. The pursuit of wealth is responsible for a large proportion of the major epidemics in history. (AIDS could be an exception, unless you place it in the context of suppressed cultures, a la slavery and colonization.) Last year 95% of the HIV infections in the world occurred in the 3rd world.
Epidemics are ignited by movements of capitol -- be they sailors, soldiers, or natives. A decision is made to transport a virgin population to a germ's homeland or to transport the germ to an unprepared city, all in the pursuit of wealth. In North America, measles and smallpox reduced a population that rivaled Europe's in 1491. The American plains and forests were not empty when Columbus arrived. But they were soon after. Disease reduced Mayan and Incan cultures to one-tenth their previous size. As many as 130 million indigenous people lived in Central and South America in 1491; 1.6 million a few generations later. Rock beats scissors, scissors beats paper, paper beats rock, but germs beats guns and nothing beats germs.
So what's it all mean?
Epidemics are political -- even when they aren't. They change the balance of power. They come about when one group is grabbing power. Be it the newest faux epidemics -- the epidemic of obesity, or school violence, or violent media -- to the more microbial sort. When epidemics appear, we should quickly try to isolate the human source of the contagion.
So is the same mechanism true for the ADHD epidemic sweeping through America's schools? Possibly. Let's ask ourselves this: Would this epidemic be so vast if money were not to be made?
-DK
News & Reviews
NEW BOOKS
Attention Deficit Disorder : A Different Perception
by Thom Hartmann, Edward M. Hallowell, Michael Popkin
Argues that ADDers are uniquely gifted individuals in their own right.
--www.amazon.com/exec/obidos/ASIN/1887424148/top100
Attention, Genes and Attention Deficit Hyperactivity Disorder
by Florence Levy, DA Hay
Reviews behavior genetic and molecular genetic advances in ADHD, including twin studies, diagnostic approaches, family and genetic influences on speech and language, and comorbidities.
--www.amazon.com/exec/obidos/ASIN/1841691933/top100
Neuropsychosocial Intervention: Treatment of Severe Behavioral Dyscontrol After TBI
by Robert L. Karol
Outlines the nature and significance of behavioral dyscontrol, explains aggression, and details the neuropsychosocial treatment approach and the principles on which it is based. Case vignettes.
--www.amazon.com/exec/obidos/ASIN/0849312442/top100
Exploratory Analysis and Data Modeling in Functional Neuroimaging
by Friedrich T. Sommer (Editor)
A survey of theoretical and computational approaches to neuroimaging, including inferential, exploratory, and causal methods of data analysis.
--www.amazon.com/exec/obidos/ASIN/0262194813/top100
Alternative Medicine and Multiple Sclerosis
by Allen C. Bowling
Complementary and alternative medicine for multiple sclerosis
--www.amazon.com/exec/obidos/ASIN/1888799528/top100
Neuroimaging: Clinical and Physical Principles
by Robert A. Zimmerman, Wendell A. Gibby, Raymond F. Carmody
Covers modern imaging modalities and techniques, emphasizing practical solutions to everyday problems. Technical.
--www.amazon.com/exec/obidos/ASIN/0387949631/top100
Localization and Neuroimaging in Neuropsychology
by Andrew Kertesz
Comprehensive review of theory and methodology in the field, circa 1994.
--www.amazon.com/exec/obidos/ASIN/012405045X/top100
Functional Neuroimaging in Child Psychiatry
by Monique Ernst, Judith M. Rumsey
Recent developments of functional neuroimaging techniques; implications for child psychiatry.
--www.amazon.com/exec/obidos/ASIN/0521650445/top100
Quantitative EEG and neurocognition in methamphetamine-dependent volunteers.
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QEEG provides a sensitive measure of methamphetamine-associated alterations in brain function.
EEG biofeedback vs. placebo treatment for ADHD
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The Terrace effect (running a poorly designed or analyzed experiment and make claims about well-run studies) exerts itself in neurofeedback.
Seizure Expression During Electroconvulsive Therapy
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EEG features associated with ECT efficacy may reflect individual differences in inhibitory processes that terminate the seizure.
EEG correlates of sound-induced affect
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Sound-induced positive affect increases relative left-sided frontal activation and negative affect right frontal activation.
Neurobiological consequences of childhood trauma.
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Adverse early-life experiences have a profound effect on the developing brain, and the consequences of early-life stress are reviewed.
Lessons for neuropsychology from functional MRI in patients with epilepsy.
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Reorganization of cognitive and motor function favors the activation of contralateral homotopic areas.
Structural and functional brain changes in PTSD
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The hippocampus, amygdala, and medial frontal cortex differ in PTSD from normals.
Functional reorganisation in patients with right hemisphere stroke
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In patients with alertness deficits due to right hemispheric vascular brain damage, improvement was found only if the RH was activated by training.
Efficacy of methylphenidate for treating adult ADHD
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MPH (ritalin) is efficacious for treating adult ADHD and in circular logic, according to the authors, this means adult ADHD is a valid diagnosis because Ritalin remediates its symptoms.
Epilepsy and videogames.
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Overview of the literature os videogame-induced seizures, beginning with the first case in 1981. Preventive measures on flash rate, choice of colors, patterns, and contrast and 100 Hz screens are recommended.
Modulation of cortical-limbic pathways in major depression
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Treatment response for cognitive behavior therapy was associated with increased metabolic changes in hippocampus and dorsal cingulate and decreases throughout the frontal cortex.
Linking Hemodynamic and Electrophysiological Measures of Brain Activity
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The relation between ERPs and fMRI differs across brain regions.
Nature of traumatic memories: a 4-T FMRI functional connectivity analysis.
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PTSD is associated with lateralized differences of brain connectivity, with decreased connectivity in multiple left brain regions but increased in some right brain regions.
Low-Field Magnetic Stimulation in Bipolar Depression Using an MRI- Based Stimulator.
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Echo-planar magnetic resonance spectroscopic imaging induces electric fields that are associated with reported mood improvement in bipolar disorder.
Upcoming CoursesA Pathway to Brain Regulation - Neurofeedback helps improve neuroregulation. It's used by health care professionals for ADHD, depression, anxiety disorders, LD, mood disorders, and behavioral problems. This 4-day course, Neurofeedback in a Clinical Practice, provides the basis for using Neurofeedback clinically. - *28 CEs
Our course is a hands-on experience right from the start. Attendees consistently say this format is a very good way to learn Neurofeedback. "Neurofeedback should be viewed as one of the three essential or primary forms of intervention - psychotherapy, psychopharmacology, and Neurofeedback. In my experience, Neurofeedback is every bit as important and powerful as the other two forms of treatment." - Dr. Laurence Hirshberg of Brown University Medical School, a psychologist specializing in Developmental Disorders and Autism. Contact Karie Kramer, our training coordinator, for more information 818-789-3456 ext 847 or see www.eegspectrum.com/Training *EEG Spectrum International, Inc. is approved by the APA to offer continuing education to psychologists. ESII maintains responsibility for the program. |
Conferences for Neurofeedback Clinicians & Researchers | ||
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| CONFERENCE | LOCATION | DATES |
| AAPB - http://www.aapb.org | Colorado Springs, CO | Apr 1-4 |
We are all misfits. Degenerates.
Last week it was discovered that 2.4 million years ago the hominid line underwent another "fortunate monster" stage of evolution. Charles Darwin spoke about fortunate monsters: most mutations kill the child or fetus, but a sparingly few actual help it along and make it king of the class. All new species undergo a monster phase. In our case, one of our genes mutated, horribly disfiguring our face, and this was a good thing (I think -- for it led to our intelligence, but it has yet to be proven that intelligence has any survival value, so maybe it wasn't....). Our recent disfigurement was a reduction of jaw muscle. With less muscle, we didn't need a sagital ridge atop our skull, you know the ones, that fancy jutting of bone our "more attractive" robust ancestors possess. The ridge anchored powerful jaw muscles, but when we became mandibly-challenged, out went the ridge and in came a thinner skull and the plasticity to balloon out.
We are the gracile version of the gracile version of the gracile version of the great apes of Africa, circa 25 million BCE. In other words, any more estrogen and there wouldn't be a male version of our species (hmmm, is that a bad thing?). We are the most estrogenized ape alive, which explains why males acquire the feminine aspects of cognition that allow for spoken language. Who else is going to pay attention to the flittering inside one's head, and think that others are doing the same? Certainly not males.
Returning to mutation... Which is better, the threat of lethal bites, or elbow room in the skull? For 80 primate species, threat of death. Bites rule. The MYH16 gene builds major components of the masseter and temporalis jaw muscles. Every living primate has a functioning MYH16, except us. In fact the gene went unnoticed because in humans, it was completely disabled by a tiny mutation. So it turns out that our mouths were the epicenter of humanity. Somehow that makes intuitive sense (he writes, speaking aloud as he does).
So what's the relevancy to mental health?
We are the offshoots of a few hairless apes that emerged 120,000 years ago in a remote region of Africa. We are adapted for THAT environment, not this one. Psychiatry is one of the last disciplines to catch Darwin-fever, but it will probably take off when it does. Evolutionary forces are the source of mental disorders. Evolution cripples the modern-day city-dwellers as it raises the bushmen. We are not adapted for living in a Chicago, or the cold of upstate New York, or any part of the industrial world. The environment of evolutionary adaptedness, they call it -- savannah, or coastal South Africa (depending upon which anthropologist you talk to). That is where we belong; that is where the human mind reached the pinnacle of fitness -- and where our thoughts are still.
We long for savannah, open spaces, carnivore predators, 150 tribal faces and no more. Psychiatric theories and treatments that fail to take account of the evolutionary adaptedness of depression, schizophrenia, autism, bipolar disorder, and a host of other disorders will undoubtedly suffer the fate of evolution, sooner or later, and go the way of the dodo bird.
-DK