What's New in Neurofeedback

A Monthly Summary of News and Events

Vol. 2 No. 7 - July 1999

This newsletter is sponsored by EEG Spectrum International, Inc.,
a leader in providing clinical service and training professionals.

Past issues are available at www.eegspectrum.com/newsletter/
Information on how to subscribe or cancel a subscription appear at the end.
The opinions related in this newsletter reflect those of the author only.
Copyright (C) 1999 by EEG Spectrum International, Inc. All rights reserved.



  • Announcements  - Media story
  • In the Spotlight   - Upon a peak in Darien
  • News & Reviews - Books, journal papers, of interest
  • Events & Locations - Conferences, Courses; New clinicians / offices
  • Last Word               - Information wants to be free

  •  

    Announcements

     


    In the Spotlight

    Upon a peak in Darien
    by David Kaiser

    Two important and related papers were recently published by Richard Davidson's lab ( Laboratory of Affective Disorders at U Wisconsin): Relations between PET-derived measures of thalamic glucose metabolism and EEG alpha power; and Thalamic metabolic rate predicts EEG alpha power in healthy control subjects but not in depressed patients. Davidson has spent the last 25 years investigating brain mechanisms and processes responsible for the generation and regulation of affective and motivational states. His lab uses quantitative electrophysiology (QEEG), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) with normal and clinical populations. Early work found an association between positive and negative emotions and asymmetric activation in the frontal lobes, usually measured by QEEG. Their recent work examined the mechanism which is responsible for alpha activity in the human QEEG.

    I had hoped to describe and discuss both papers, but UCLA's Biomed library, using bureaucratic logic, no longer subscribes to Biological Psychiatry, a major journal and one in which the second of these two papers was published (See Last Word below for a rant on this development). So my discussion of their 2nd paper, published this April, is solely gleaned from the abstract.

    "Relations between PET-derived measures of thalamic glucose metabolism and EEG alpha power" (Psychophysiology, 35, 162-169) provides the first direct evidence of what we in the EEG field always presumed was true, that alpha activity present at scalp recordings reflects thalamic activity. Since the 1940s, the thalamus has been thought to modulate cortical alpha rhythms. A substantial body of data from animal work supports this idea. Evidence from decorticate cats indicated that rhythmic oscillations in the 8-12 Hz range occurred in the thalamus and were present independent of cortical connections. Thalamocortical coherences are typically higher than corticocortial coherences, again suggesting that the thalamus is greatly involved in the generation of the middle frequency range. In the mid-1980s, Steriade proposed that the nucleus reticularis, a sheath of cells around the thalamus which projects to nearly all thalamic nuclei, is the true pacemaker. Thalamic cells have intrinsic firing rates, but it is this enveloping sheath which synchronizes firing rates into 8-12 Hz bursts.

    For the better part the mystery was solved -- at least in animals. But speciation rears its head and asks, what about humans? Is the mechanism responsible for alpha activity in animals the same in humans? Given that most Human Subject Protection Committees frown on decortication or other invasive techniques, we must turn to neuroimaging and less direct measurements.

    Neuronal activity requires energy, and this energy is primarily found in the brain in the form of glucose. Measuring glucose metabolism provides a good estimate of overall synaptic traffic (cf. Roland, 1993; Astrup et al, 1981). Astrup et al (1981), for instance, anesthesitized dogs to the point of no detectable electrical activity and reported 30% less glucose consumption during this state. Further blocking of energy-consumptive neuronal processes dropped glucose consumption down to 35% of baseline. (Any further study of reduction would kill the animal.) Because glucose molecules are very difficult to detect inside a darkened skull, the technique pivots around adding a few radioactive molecules to the mix. (Whereas QEEG is founded on electromagnetism, PET's success lies with the weak nuclear force. Can the use of gravitons in neuroimaging be far behind?) A sugar solution, with a few unstable isotopes scattered here and there, is injected into a suspecting subject. Radioactive decay of the isotopes produces positrons at predictable rates. These emissions are monitored with a sophisticated geiger-counter, of sorts, which generate near-3-dimensional images. If you've ever played the game Black Box (http://www.rad.kumc.edu/share/win31/games/misc/LASER.ZIP), in which you identify the configuration of marbles in a grid from reflected beams, you understand the basic principles behind tomography. (Obviously I'm simplifying -- though trying not to be too simple. MRI is the closer analog to the game, as the beams are generated within the grid in PET and outside the grid in MRI, like the game)

    A fair amount of time must pass to accrue and accurately count the products of radioactive decay from any one location. As Larson states, "... the temporal resolution of PET is vastly inferior to that of EEG". In this study radioactivity was collected for 30 minutes. Accordingly, EEG activity was recorded for 30 minutes, averaged for five sets of eyes closed and eyes open periods, interlaced across the 30 minutes. EEG data was acquired from 28 sites -- the standard 19 sites, minus O1 and O2, plus FT3 (halfway between F3 and T3), FT4, FT7, FT8, CP3, CP4, CP5, CP6, PO3, PO4, and FPZ. (I guess they too realized how rarely occipital activity correlates with cognitive function.) Of interest to those who haven't practice in PET arts (which includes myself), the important PET measure was a single pixel in the right thalamus. This pixel represented the entire thalamus, which was partly justified as it was generated with a Gaussian filter so that neighboring pixels greatly influenced it, essentially making it a spatial average. The global output of the PET was also analyzed. Two groups of subjects were used in this study, depressed patients and controls.

    Multiple correlations of pixel intensity and log alpha power were calculated. They found no significant differences between the two groups -- at least for this approach -- so they combined them. The correlation between thalamic metabolic activity and alpha activity was rho = -.59 in the eyes open condition and r=-.52 during eyes closed. Alpha activity was also analyzed for low (8-10 Hz) and high (10-13 Hz) bands, and left and right hemisphere, without any new results. Overall, 65% to 75% of variance still remains unaccounted for, but given the limitation and error inherent in current technologies, these correlations are very convincing.

    These finding suggest a relatively tight coupling between thalamic activity and scalp EEG recordings in the alpha range. Whether the thalamus is solely responsible for the alpha amplitudes is not entirely certain; but it is clear that its involvement is great. Paul Nunez argues against the thalamo-dominant thesis -- instead, according to his argument, thalamic rhythms become "coincident with neortical rhythms". This, the neocortical modulation hypothesis, argues that the larger neocortical responses generates the thalamus's marching orders, synchronizing the thalamic neurons, with great frequency plasticity, with their more evolved, bullying, upstairs neighbors. This has yet to be determined, and will require an even more elegant and clever design.

    One limitation of the described approach (from the 1st paper) was lack of isolation of the thalamus. The location of the thalamus was obtained indirectly, by using atlas-based coordinates over the entire PET output. The second paper corrected this, using structural MRI to isolate the thalamus, to thus better measure its activity. (For instance, no spatial filtering was needed with this method.) In the latter paper, the expected robust correlations between metabolic activity in the thalamus and alpha activity on the scalp were observed in normal subjects, but these correlations were missing in depressed patients. Something was amiss in these poor fellows' brains. Lindgren et al argued, according to the abstact, for a "possible abnormality in thalamocortical circuitry associated with depression". What a great finding! And so relevant to neurofeedback!

    If the thalamocortical circuitry is broke, let's find a way to fix it, retrain it. Let's see how well those correlations can be used to identify depression, classify its subtypes. Will these correlates appear in other mood disorders, anxiety, OCD? And still more -- can we use these correlations to measure treatment response? Effectiveness and efficacy of neurofeedback, Prozac, etc.?

    I'm reminded of the English poet John Keats, who upon reading a recent translation of Homer, felt that an entirely new world had been lain at his feet. He quickly put pen to paper to capture his heart-felt response -- of discovery, both virginal and vast. Like an astronomer who discovers a new planet in his telescope, or better yet, like "stout Cortez" when first set eyes on the Western shores of our largest and deepest body of water, the Pacific, the first white man to do so. Keats was thunderstruck by what he read. (Granted, Keats was no historian as Balboa was the one who first saw the Pacific through European eyes. But such is the poetic mind, able to reveal indescribable emotion with conveniently imprecise details. Cortez -- just the sound of it is sturdy and stout, unlike "Balboa", whose name illicits corpulence more than strength.)

    Unlike Keats, I was not struck silent by this discovery, nor was the impact so life-altering for me as it was for Keats (this poem ignited his career), but I did walk into Siegfried Othmer's office the morning after I read the abstract and said that if he hadn't checked his email from the previous night (where a copy of the abstract awaited him), he was unaware that the scientific landscape had been recast. At least in terms of neuropsychiatry. An apparatus was now in place, powered by neuroimaging, ready to capture the future of neuropsychiatry and funnel it toward one obvious conclusion: neurofeedback.


    Related Reading:

    On first looking into Chapman's Homer.

    Much have I travell'd in the realms of gold,
    And many goodly states and kingdoms seen;
    Round many western islands have I been
    Which bards in fealty to Apollo hold.
    Oft of one wide expanse had I been told
    That deep-brow'd Homer ruled as his demesne;
    Yet did I never breathe its pure serene
    Till I heard Chapman speak out loud and bold:
    Then felt I like some watcher of the skies
    When a new planet swims into his ken;
    Or like stout Cortez when with eagle eyes
    He star'd at the Pacific--and all his men
    Look'd at each other with a wild surmise--
    Silent, upon a peak in Darien.

     


     

    News & Reviews

    NEW BOOKS

     

    Understanding, Diagnosing, and Treating Ad/Hd in Children and Adolescents : An Integrative Approach
    by James A. Incorvaia (Ed)

    An integrative approach to treating ADHD, with multiple chapters on the efficacy of neurofeedback on ADHD. Dennis Cantwell provides a 10-year review on ADHD, Lawrence Greenberg describes the use of TOVA, Marcel Kinsbourne on a subtype of ADHD, Daniel Amen on Spect imaging of ADHD, and the Othmers and myself, and Thomas Brod in a separate chapter, discuss EEG biofeedback.
    http://www.amazon.com/exec/obidos/ASIN/0765701847/top100

     

    Interventions for ADHD: Treatment in Developmental Context
    by Phyllis Anne Teeter

    Examines ADHD from a developmental perspective. Shows how ADHD affects individuals at different points in the lifespan. The author, a Professor of Educational Psychology at the University of Wisconsin, helps clinicians recognize the major developmental milestones, issues, and challenges for clients with ADHD, evaluating intervention strategies and techniques for aiding preschoolers, school-age children, adolescents, and adults.
    http://www.amazon.com/exec/obidos/ASIN/1572303840/top100

     

    Brain Function and Oscillations: Integrative Brain Function
    by E. Basar

    The functional importance of the brain's multiple oscillations is treated with an integrative scope. Electrophysiology of human and animal brains, including ganglia of invertebrates. Experiments on sensory registration, perception, movement, and cognitive processes related to attention, learning, and memory are described.
    http://www.amazon.com/exec/obidos/ASIN/3540643451/top100

     

    Strong Feelings: Emotion, Addiction, and Human Behavior
    by Jon Elster

    The author argues how cognition, choice, and rationality are undermined by the physical processes that underlie strong emotions and cravings. Although emotion and addiction involve visceral motivation, they are also closely linked to cognition and culture.
    http://www.amazon.com/exec/obidos/ASIN/0262050560/top100

     

    Rehabilitation of the Adult and Child With Traumatic Brain Injury
    M Rosenthal, JS Kreutzer, ER Griffith, MR Bond (Eds)

    A resource for clinicians and students in health care and related professions. Includes sections on pediatric injuries, therapeutic recreation, and legal aspects.
    http://www.amazon.com/exec/obidos/ASIN/0803603916/top100

    Perspectives on Learning Disabilities : Biological, Cognitive, Contextual
    by Robert J. Sternberg, Louise Spear-Swerling

    Experts from biological, cognitive, educational, sociological, and interactive perspectives to discuss the nature of LD, its origins, its diagnosis, and effective remediation.
    http://www.amazon.com/exec/obidos/ASIN/0813331757/top100

    Sleep Disorders Sourcebook
    by Jenifer Swanson

    Basic Consumer Health Information About Sleep and Its Disorders, Including Insomnia, Sleepwalking, Sleep Apmea, and Restlessness
    http://www.amazon.com/exec/obidos/ASIN/0780802349/top100

     

     


    JOURNAL PAPERS

    Hypofrontality in ADHD during higher-order motor control: an fMRI study.
    --ADHD is associated with subnormal activation of the prefrontal systems responsible for higher-order motor control. Functional MRI is a feasible technique for investigation of neural correlates of ADHD.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10360128

    Anterior cingulate cortex dysfunction in ADHD
    --The Counting Stroop produced anterior cingulate activation in healthy adults, but not in ADHD individuals. ADHD subjects did activate a frontostriatal-insular network, as expected. The data support a hypothesized dysfunction of the Anterior cingulate cognitive division in ADHD.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10376114

    EEG correlates of methylphenidate response among children with ADHD
    --Children who exhibit a positive response to methylphenidate for ADHD had reductions of theta and alpha activity as well as increased beta in the frontal regions, while nonresponders showed the opposite pattern. Significant correlations between improvement on a vigilance task and changes in beta activity in the frontal electrodes emerged as well. the authors conclude that there are different electrophysiologic correlates to methylphenidate among ADHD children who are medication responders and nonresponders.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10376129

    Intellectual and neuropsychological features of patients with psychogenic pseudoseizures.
    --Studies have suggested that patients with psychogenic pseudoseizures may also have impaired neuropsychological function. A high incidence of impaired performance on the Halstead-Reitan Neuropsychological Battery was found. The authors postulate that head trauma might be responsible for neuropsychological impairment in an appreciable number of the patients in this sample.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10359484

    Posttraumatic stress symptoms in children following traumatic brain injury.
    --Examined posttraumatic stress (PTS) symptoms in children following pediatric traumatic brain injury (TBI). Parents of children with severe TBI reported higher levels of child PTS symptoms than did parents of children with moderate TBI or OI at the 6- and 12-month follow-ups.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10353082

    Transcranial magnetic stimulation for the treatment of resistant major depression.
    --Repetitive transcranial magnetic stimulation (rTMS) did not differ from sham treatment in treating depression (controlled randomized design, 18 subjects).

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10360138

    Sources of abnormal EEG activity in the presence of brain lesions.
    --Results from a group of 13 patients with cortical space-occupying lesions provided strong support to the hypothesis that both delta and theta abnormal EEG activities are the counterparts of two different pathophysiological processes.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10358783

    Symptom-based predictors of a 10-year chronic course of treated depression.
    --Potential symptom-based risk factors were used to predict a chronic course of treated depression over a 10-year interval. Chronically depressed patient typically exhibit more severe symptoms of fatigue, loss of interest in usual activities, trouble sleeping, and thoughts about death or suicide; are not calm, successful, nor self-confident; and do not socialize with friends outside the home, and frequently coped with stressors by avoiding other people. The more risk factors exhibited, the more likely one would experience a chronic course. High-risk patients who received more psychological treatment, however, often underwent full or partial remission.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10379723">

    Validation of a right hemisphere vigilance system with QEEG
    --QEEG during CPT task indicates the existence of a neurophysiological system located within the right temporal region that appears essential for the maintenance of a sustained attentional state. This neurocognitive system may prove useful as part of a clinical diagnostic workup.

      Further info: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=6&db=m&Dopt=b&uid=10380946

     


     

    Events & Locations


    Advanced Training Courses

    BETA/SMR Advanced Practicum
    with Sue Othmer

    Topics Covered
    Evaluating Raw EEGs
    Spectral Density
    Choosing Inhibit Filters
    Coherence Training
    New Protocols
    Discussion of Difficult Cases
    Clinical Strategies/Testing

     

    Alpha-Theta Advanced Practicum
    with Bill Scott

    Topics Covered
    Guided Imagery
    Interpreting Imagery
    Working with Addictions
    Facilitating Cross-Over
    Recognizing Progress
    When to bring in BETA/SMR
    Alternative Protocols


    1999 Schedule
    Encino, California BETA/SMR Advanced Practicum 9/22/99 Wed
    Encino, California Alpha-Theta Advanced Practicum 9/28/99 Tue
    New York, New York BETA/SMR Advanced Practicum 10/12/99 Tue
    Austin, Texas Alpha-Theta Advanced Practicum 11/23/99 Tue
     
    Beta-SMR Advanced Practicum Limit = 20 | Alpha-Theta Advanced Practicum Limit = 15
    DATES*COSTS*LOCATIONS SUBJECT TO CHANGE

      PREREQUISITES FOR EITHER PRACTICUM:
    • Completion of 1 EEG Spectrum International Biofeedback Training Course for Professionals
    • EEG Biofeedback experience using NeuroCybernetics Instrumentation


    Conferences for Neurofeedback Clinicians & Researchers

    CONFERENCELOCATION DATES
    SNR 1999 Myrtle Beach, SC Sep 30-Oct 3, 1999

     


    New Neurofeedback Clinicians / New Offices

    Laurence Starr, Ed.D.
    21 Mechanic St.
    Camden, ME 04843
    (207) 236-2893; Fax -0654
    lstarr@midcoast.com
    
    A.D.D. Treatment Center
    Gary J. Schummer, M.Div., Ph.D.
    24050 Madison St., Suite 111
    Torrance, CA 90505
    (310) 378-0547; Fax-0347
    ADDCenters@cs.com
    
    Daniel Parker, D.C.
    Duc Ngoc Tran, D.O.
    Cooperative Care Medical Group
    27062 La Paz Rd.
    Aliso Viejo, CA 92656
    (949) 362-9230
    
    Ron Bruder
    43 W. Washington
    Newnan, GA 30263
    (404) 765-7454
    rbruder@mail.newnanutilies.org
    
    Earlene Strayhorn,M.D.
    1022 S. Oak Park Ave
    Oak Park, IL 60304
    (708) 750-4360
    stanwest@msc.com
    
    Andrea J. Sime, LMSW
    Lincoln Beh. Healt Clinic
    1919 S 40th St, Suite 212
    lincoln, NC 68506-5243
    (402) 441-9280
    asime@inetnebr.com
    
    Dr. Shandor Weiss
    Arura Clinic
    233 4th St
    Ashland, OR 97520-2043
    (541) 488-1198
    
    J.D. Elder, M.S., P.T.
    1598 W Brook View Lane
    St. George, UT 84770
    (435)-673-7081
    elder@infowest.com
    

     

    Last Word

    Information wants to be free
    by David A. Kaiser, Ph.D.

    Ever take a family pet to the vet? Be it teeth cleaning, jaw reconstruction, or reproductive snipping, whatever the catastrophe, something always astounds me about the vet. I've taken cats with lymphoma, immune disorders, and acronyms I now forget across town. Most recovered after the trip, a few did not. When my largest cat decided to spend two or three of his nine lives awhile back, having contracting "fever of unknown origin", the overnight stay in the animal hospital cost 180 dollars. $180 for room and board and a healthy dose of poking and prodding and drugs. Had these procedures been performed on a human in a hospital, which I wouldn't recommend, the bill would have staggered us. But because a veternarian carried out the procedure, it cost a (relative) pittance.

    A few years ago my father shelled out $600 to treat Stevie. It was a fortune, he still reminds us to this day, but it was also the last pet still with us from our childhood. And you should have seen what the vet had to work with. We gave the vet a 12-year old cat unable to climb stairs, too feeble to eat, full-body shivers, and the weakest purr you ever heard. A week or so later, we got back five more years -- happy, healthy, purring like a motorboat, years. 33 cents a day, when you figure it out. Money well spent.

    You can't charge more than the animal is worth, they say. Charge too much and Fluffy becomes a permanent guest. ($600 came very, very close to that limit.)

    But this adage is not really true for this profession. Given the importance of the family pet to the mental and emotional health of the children underfoot, a vet could easily charge 10 or 15 times more, knowing full well that Mother will make Father pay it in full. But this hasn't yet happened.

    We've all paid extortionate prices for an item or two in our lives, and more and more companies and institutions are realizing how much blood can come from stone, but I'm happy to find certain professionals bringing up the rear on this business practice. But now we've reach my primary concern. Academic publishing. It may not be grand marshal of this parade, the Blood-out-of-Stone Extravaganza, but it also isn't the local junior high school band bringing up the rear.

    Last week I spent four hours in the biomedical library, searching in vain for a handful of recently published papers; only to learn that UCLA, home of the Brain Research Institute, no longer subscribed to a good third of the journals I required. And these were mainstream scientific journals. What particularly irked me was the absence of recent volumes of Biological Psychiatry, one of the few journals I have come back to again and again. Why had the bureaucrats at UCLA decided against subscribing to such a useful journal? That was my question/my quest.

    A brief foray into cyburbia revealed the answer... $ 1525.00...   the cost for one-years subscription.

    Surely by accident the decimal point migrated one place eastward for the summer, don't you think? I could understand 150 dollars for a year of thick (and not so thick) journals, but 12 or 24 issues for the price of a big-screen TV? Never! For their fortune UCLA would acquire about 2000 pages of text and a score of color figures, all in softcover. For the same amount, a dozen or so textbooks could be purchased, hard bound, glossy pages, 6000 pages or more. (Or better yet, 146 paperback editions of The Fermata, a sexy story of time stoppage, 35,000 pages, very interesting and highly-readable pages.)

    Is Biological Psychiatry worth each year a large-screen TV? Can the publisher justify the prices they charge libraries? "Well, given the limited run, the importance of the work, the newly invented color-laminating-dye process, blah blah blah" The real question to ask is should the dissemination of scientific knowledge be so hindered.

    A quick search of the publisher's website revealed the prices:

    JournalPer Year Per issue
    Aggression and Violent Behavior $ 318 $ 80
    Behavioural Brain Research $ 3197 $ 159
    Biological Psychiatry $ 1525 $ 64
    Drug and Alcohol Dependence $ 1138 $ 95
    Journal of Affective Disorders $ 1726 $ 115
    Journal of Neuroscience Methods $ 2878 $ 159
    Journal of Psychiatric Research $ 699 $ 117
    Neuropsychologia $ 1919 $ 148
    Neuroscience $ 5365 $ 192

    Compared to other journals, at $64 every two weeks, Biological Psychiatry was a bargain....

    The same website boasts a "Neuroscience Package" with great savings for librarians -- 9 journals for only $18,985.00. Get serious. Mortgages are lower! Hire a thousand typing monkeys and stand back. Granted, these are all "institution prices" and an individual can typically subscribe for 10% of the price, but charging an institution a 900% markup over private subscriptions hurts everyone (except the publisher, of course). This publisher is not alone in setting skyhigh prices for academic journals. Nowadays most academic periodicals cost the same as the thicker and better produced textbooks, often sold by the same publisher. There must be a better way.

    And of course there is. The Internet; the Web. I realized the power of web publishing last year when articles I had written solely for online readers were cited five times in recent printed journals. (All that and no fickle peer-review.... hmmmm.)

    My favorite journal, Behavioral & Brain Sciences (BBS), has a preprint archive online - http://www.cogsci.soton.ac.uk/bbs/Archive/. The archive actually generates content for the printed journal by attracting commentaries that are only published in the paper version. Tonight I discovered Paul Nunez's most recent paper on EEG in this archive, a paper not to be printed in ink for another year. Online publishing is gaining ground on printing house, due to its many advantages, speed just being one of them. Another is searchability. Try searching for any article published before 1964. A third is easy re-distribution. A fourth is easy modification -- or is that a disadvantage. A fifth is the nature of thought, which is rarely serial and better served by hypertext than constant authorial dictation. Online can also be a dumping ground, for good and evil, of animations, sounds, and other supplementary information that clarifies or supports one's published work.

    Like BBS, the Journal of Neurotherapy follows a similar tack, placing entire issues online one year after publication. Other journals provide full text articles online to print subscribers or charge a cheaper rate than print subscriptions for their viewing. ...Merely fingers in the dike.

    Physicists are breaking free from brick-and-mortar publishing houses altogether. arXiv.org e-Print archive at http://xxx.lanl.gov/ distributes full text preprints of articles in every conceivable (and inconceivable) field of physics. This has been going on since 1991. Physicists have also created entire peer-reviewed e-journals without ink-and-paper counterparts. Molecular biologists have also read the handwriting on the monitor and followed suit. For example, check out Molecular Vision, a new e-journal, which, like the tree-based mediums, has its contents indexed in Medline, PubMed, Index Medicus, Science Citation Index, Current Contents, etc. And most importantly, access to this journal is entirely free of charge.

    Which coincidentally happens to be the price of this newsletter.

    Because information wants to be free.