Research Articles, 2000-2003

  1. Pharmacokinetic considerations in the treatment of ADHD with methylphenidate.
    Methylphenidate is a rapidly absorbed medication that readily penetrates the CNS, particularly the striatum. [more]

  2. Differential effects of methylphenidate on attentional functions in ADHD.
    Intensity-dimension attentional functions are best influenced by higher doses, executive functions by moderate doses, and selectivity-dimension functions by variable doses. [more]

  3. Efficacy of methylphenidate for treating adult ADHD
    MPH (ritalin) is efficacious for treating adult ADHD and in circular logic, according to the authors, this means adult ADHD is a valid diagnosis because Ritalin remediates its symptoms. [more]

  4. Different dosages of methylphenidate in treating adults with ADHD
    Improvements in ADHD symptoms on methylphenidate were reported, with no difference due to dosage (10 mg x2 vs 15 mg x3) [more]

  5. Daily methylphenidate use slows the growth of children
    Height differences between treated children and sibling controls after 2 y treatment across broad range of doses (10-80 mg per day) suggest grow-suppressive effects of methylphenidate is greater than suspected. [more]

  6. ERPs of methylphenidate in children with and without ADHD.
    P300a amplitudes are lower in non-medicated ADHD patients than in healthy children during a continuous performance task; but not for methylphenidate-treated hyperactive children. [more]

  7. Neurofeedback treatment for ADHD in children: a comparison with methylphenidate.
    Both neurofeedback and methylphenidate were associated with comparable improvements on two attentional tests as were behaviors related to the disorder [more]

  8. Methylphenidate enhances both intracortical inhibition and facilitation in healthy adults.
    MPH enhances both intracortical inhibition and facilitation, which suggests it acts on the motor cortex using a neurotransmitter in addition to dopamine. [more]

  9. PET Study Of Methylphenidate in Adults with ADHD
    Methylphenidate modulates brain regions associated with motor function to achieve a reduction in ADHD symptoms. [more]

  10. Methylphenidate and substance abuse: a review of pharmacology, animal, and clinical studies.
    Although intravenous methylphenidate has some abuse potential, there is little potential for oral MPH abuse, though longitudinal studies are needed. [more]

  11. Ritalin revisited: does it really help in neurological injury?
    Methylphenidate may augment activity of injured neuronal tissue in the comatose patient, with similar action in stroke and TBI. [more]

  12. Emergence of tics in children with ADHD treated with stimulant medications.
    7.8% of 555 ADHD subjects treated with stimulants developed tics (8.3% treated with methylphenidate, 6.3% with dextroamphetamine, and 7.7% with pemoline). Subjects who developed tics were generally younger. [more]

  13. An open study of methylphenidate in bipolar depression.
    Methylphenidate was effective and relatively safe for depressed bipolar subjects. [more]

  14. What's all the fuss about Ritalin?
    ADHD is sometimes overdiagnosed but is possibly more often underdiagnosed. Pediatricians should play a proactive role in the screening, diagnosis, and treatment of ADHD. [more]

  15. Methylphenidate: its pharmacology and uses.
    The mechanism of action and efficacy of methylphenidate is reviewed in clinical conditions. [more]

  16. Deficient intracortical inhibition in drug-naive children with ADHD is enhanced by methylphenidate.
    Motor system excitability was evaluated in ADHD children using transcranial magnetic stimulation (TMS); ADHD-children had reduced intracortical inhibition compared to controls. [more]